Neuropathy in cases of Hypothyroidism as Confirmed by Motor Nerve Conduction Studies: A Prospective Study in a Tertiary Care Hospital

Background: Thyroid hormone play important role in development of Central Nervous System and in myelination of neurons. Patients of hypothyroidism may suffer from peripheral nervous dysfunction. Aim of our study is to find out the neuropathy in hypothyroidism. Methods: This prospective study was conducted on 40 subjects, out of which n=20 were euthyroid control and n=20 were hypothyroid. The Study was performed in the Medicine department of Saraswathi Institute of Medical Sciences, Hapur in collaboration with the department of Physiology at G.S. Medical College, Hapur. MNCV and latency of Median, Ulnar, and Common Peroneal nerve of both upper and lower limb were done in patients of Hypothyroidism and in Control subjects. Results: Significant bilateral decrease is observed in the MNCV of the Median Nerve in Hypothyroid subjects as compared to the control subjects. Also, there  is Significant  bilateral  increase  in the  Motor Latency of the Median Nerve in Hypothyroid subjects as compared to the control subjects. Conclusion: Hypothyroidism cause significant decrease in MNCV of Median Nerve as well as increase in Motor latency in Median Nerve.

The Evaluation of Cord Blood Magnesium Level in Neonates of Magnesium Sulphate Treated 16 Pre-eclamptic/eclamptic Mothers and its Clinical Correlation.

This case control study was carried out on 35 neonates born to pre-eclamptic/eclamptic mothers treated with magnesium sulphate and 35 neonates born to normal healthy mothers. Cases and controls were selected by inclusionexclusion criteria irrespective of body weight and maturity of the babies. Magnesium sulphate administered to mother in study group was according to Pritchard’s intramuscular regime (1984). The cord blood samples were collected just after birth in both study and control group and magnesium level was estimated by calorimetric method. Magnesium level was found to be significantly higher in study group (6.0305±0.08047) than controls (1.916± 0.300; p = 0.0001). There was a significant difference in Apgar scores of study and control group. A negative weak linear correlation was found between cord blood magnesium level and different neonatal parameter like apgar score, birth weight and gestestional age. A weak positive linear correlation was found between magnesium level and neonatal mortality which was also not significant.